Lupus erythematosus. Hymes SR, Jordon RE, Arnett FC. Lupus erythematosus represents a wide spectrum of diseases. Within this heterogeneity, however, several clinically relevant subsets have been found that may unite differing aspects of the disease and that may have pathogenic implications for the problem as a whole.

Merrill JT, Neuwelt CM, Wallace DJ, et al. Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: the randomized, double-blind, phase II/III systemic lupus erythematosus evaluation of rituximab trial.

Lupus, technically known as systemic lupus erythematosus (SLE), is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue in many parts of the body. Symptoms vary between people and may be mild to severe. Common symptoms include painful and swollen joints, fever, chest pain, hair loss, mouth ulcers, swollen lymph nodes, feeling tired, and a red rash which is 2014-04-09 The heterogeneity of systemic lupus erythematosus (SLE), long recognised by clinicians, is now challenging the entire lupus community, from geneticists to clinical investigators. Although the outlook for patients with SLE has greatly improved, many unmet needs remain, chief of which is the development of safer and more efficacious therapies. To develop innovative therapies, a far better Chilblain lupus erythematosus, Hutchinson lupus, Lupus chilblains, MIM 614415, MIM 610448, Chilblain LE. Authoritative facts from DermNet New Zealand. 2012-09-13 2020-09-03 Duron L, Cohen-Aubart F, Diot E, et al. Shrinking lung syndrome associated with systemic lupus erythematosus: a multicenter collaborative study of 15 new cases and a review of the 155 cases in the literature focusing on treatment response and long-term outcomes.

Pubmed lupus erythematosus

2016 Dec;27(6):488-e131. doi: 10.1111/vde.12389. PubMed PMID: 27747960. 11: Jha AK, Sonthalia S, Sarkar R. Dermoscopy of discoid lupus erythematosus. OBJECTIVE: Systemic lupus erythematosus (SLE) is a chronic, relapsing-remitting autoimmune disorder that involves multiple organ systems including the central nervous system. Among the items included in the nomenclature for neuropsychiatric SLE, mood disorders have been identified. Neonatal lupus erythematosus is an uncommon maternal auto-antibody-associated disease characterized by cutaneous, cardiac, hepatic, hematological, neurological, and pulmonary involvement.

Chilblain lupus erythematosus, Hutchinson lupus, Lupus chilblains, MIM 614415, MIM 610448, Chilblain LE. Authoritative facts from DermNet New Zealand.

Lupus 16 , 195–200 (2007). CAS PubMed Article PubMed Central Google Scholar 2007-01-18 · Resistance to Systemic Lupus Erythematosus. TLR5, the innate immune receptor for bacterial flagellin, maps to chromosome 1q41 and contains a common 1147C-T polymorphism that encodes a premature stop codon (R392X; 603031.0001) associated with increased susceptibility to Legionnaire disease (608556).

Systemic lupus erythematosus (SLE) is a chronic disease that causes inflammation in connective tissues, such as cartilage and the lining of blood vessels, which provide strength and flexibility to structures throughout the body.

It has a prolonged course and can have a considerable effect on quality of life. Early recognition and treatment improves the prognosis. Systemic lupus erythematosus (SLE), an autoimmune disorder which primarily affects women (10:1 female to male ratio), may affect virtually any organ.1 Predominant manifestations include non-deforming arthritis, serositis, photosensitivity, renal, haematological, and central nervous system involvement.

Symptoms and signs may accumulate over time.
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Morbidity and mortality in systemic lupus erythematosus during a 5 year period.

2021-01-19 · Background Systemic lupus erythematosus (SLE) is a multisystemic, chronic inflammatory disease characterized by destructive systemic organ involvement, which could cause the decreased functional capacity, increased morbidity and mortality. Previous studies show that SLE is characterized by autoimmune, inflammatory processes, and tissue destruction. Some seriously-ill patients could develop Lupus erythematosus is a collection of autoimmune diseases in which the human immune system becomes hyperactive and attacks healthy tissues.
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Systemic lupus erythematosus (SLE) is a systemic autoimmune disease, with multisystemic involvement. The disease has several phenotypes, with varying clinical presentations in patients ranging from mild mucocutaneous manifestations to multiorgan and severe central nervous system involvement.

Vet Dermatol. 2016 Dec;27(6):488-e131. doi: 10.1111/vde.12389. PubMed PMID: 27747960.

Duron L, Cohen-Aubart F, Diot E, et al. Shrinking lung syndrome associated with systemic lupus erythematosus: a multicenter collaborative study of 15 new cases and a review of the 155 cases in the literature focusing on treatment response and long-term outcomes.

The studies reviewed suggest that B cells from systemic lupus erythematosus patients display molecular signaling defects that most likely contribute to pathogenesis of the disease and explain the characteristic hyperactivity of B cells in active disease. The studies reviewed 2015-04-23 · A systematic search was performed in the electronic database (PubMed –NCBI) using the following search terms in all possible combinations: systemic lupus erythematosus, arterial thrombosis, vein thrombosis, risk factor, antiphospholipid antibodies, inherited thrombophilia, acquired thrombophilia, cardiovascular disease, atherosclerosis, ethnicity, treatment, antithrombotic treatment, antithrombotic prophylaxis, pregnancy, contraception, catastrophic APS. Systemic lupus erythematosus (SLE), is the most common type of lupus. SLE is an autoimmune disease in which the immune system attacks its own tissues, causing widespread inflammation and tissue damage in the affected organs. It can affect the joints, skin, brain, lungs, kidneys, and blood vessels. Lupus erythematosus is a collection of autoimmune diseases in which the human immune system becomes hyperactive and attacks healthy tissues.

Women of childbearing age and B Cell Receptor Signaling in Human Systemic Lupus Erythematosus - PubMed. The studies reviewed suggest that B cells from systemic lupus erythematosus patients display molecular signaling defects that most likely contribute to pathogenesis of the disease and explain the characteristic hyperactivity of B cells in active disease. The studies reviewed 2015-04-23 · A systematic search was performed in the electronic database (PubMed –NCBI) using the following search terms in all possible combinations: systemic lupus erythematosus, arterial thrombosis, vein thrombosis, risk factor, antiphospholipid antibodies, inherited thrombophilia, acquired thrombophilia, cardiovascular disease, atherosclerosis, ethnicity, treatment, antithrombotic treatment, antithrombotic prophylaxis, pregnancy, contraception, catastrophic APS. Systemic lupus erythematosus (SLE), is the most common type of lupus.